Facile Synthesis of 3,4-Bis(2-methoxyethoxy) Benzonitrile

3, 4-Bis(2-methoxyethoxy)benzonitrile can be synthesized from 3, 4-bis(2-methoxyethoxy)benzaldehyde, but the traditional synthetic method required harsh reaction conditions and long reaction time. 3, 4-Bis(2-methoxyethoxy)benzaldehyde and hydroxylamine hydrochloride were conducted in formic acid using a certain amount of pyridine as catalyzer. The reaction can be finished within 1 h at the reflux temperature of formic acid. The yield of 3, 4-bis(2-methoxyethoxy)benzonitrile is above 92% and its purity is higher than 98%.